Endocrine Abstracts

To examine the hormonal characteristics related to age of reproductive axis, serum hormone profiles and inhibins A and B were investigated in fertile and menopausal women.Subjects: Forty-three cycling women (23–40-year-old) and 75 menopausal women (55–70-year-old) were studied. Serum 17-OHP, DHEA, DHEAS, androstendion, estradiol, estrone, progesterone, testosterone, free testosterone, DHT, SHBG, inhibin A and inhibin B, LH, FSH, Prl, TSH, GH, I...

Inhibin B is a product of the gonads and it is a marker for ovarian follicular development. We studied leptin, inhibin B and LH levels in two groups of patients with AN, at low weight (n=20, BMI=14.3 plus/minus 0.3 kg/m2) and after they reached goal weight and restore menstrual cycles (n=13, BMI 19.3 plus/minus 1.0 kg/m2). Nineteen eumenorrheic females (BMI 19.8 plus/minus 0.4 kg/m2) served as controls. At low weight in patients with AN, basal leptin (1.1 plus/minus 0.2 ng/L),...

‘HM’ 39-year-old.TAH & BSO 1 year ago for mennorhagia and endometriosis, at another hospital. No serious pathology.Patient c/o hot flushes, lethargy, mood swings and low libido.Treated by GP for frequent migraines but no visual problems.Family h/o Cardio-Vascular disease;Grandfather MI RIPFather MI Alive & well<p class=...

Natriuretic peptides, ANP, BNP and CNP, exert the majority of their effects via particulate guanylyl cyclase receptors (GC-A or GC-B), resulting in increased cellular cGMP levels. Several studies have examined the pharmacological properties of GC-B receptors in many systems, and desensitization (tachyphylaxis, loss of response) has been reported to occur. Targeted deletion (in mice) or genetic mutations (in humans) of the GC-B receptor have been implicated in a dwarfism phenot...

Introduction and aimGraves’ disease which is the most common cause of hyperthyroidism is an autoimmune disease presenting with goitre, orbitopathy and dermopathy. The disease is caused by stimulant type TSH receptor antibodies (TRAB). TSH receptor (TSHR) has been shown in different tissues other than thyroid. Testis is one of the extrathyroidal tissues with TSHR. The aim of this study was to investigate relationship between TRAB and inhibin-B, whic...

Purpose: Studies have shown that testosterone levels were associated with cognitive function, depression and sleep quality in general population. However these relationships between testosterone, cognitive function, depressive behavior, and sleep quality in chronic renal failure (CRF) patients not on dialysis were not evaluated before.Methods: All patients underwent history taking, physical examination, blood pressure measurement, routine urine and bioch...

Varicocele is a state of varicosity and tortuosity of the pampiniform plexus around the testis caused by retrograde blood flow. The association between varicocele and male subfertility has been questioned, thus the usefulness of treating varicocele in order to improve fertility is still a matter of debate. Inhibin B levels reflect the functional state of the seminiferous epithelium, and have been found to be a sensitive index of spermatogenesis. Serum inhibin B levels have bee...

B Allolio, Department for Endocrinology and Diabetes, University of Wuerzburg, Wuerzburg, Germany AbstractBruno Allolio received his Bachelor of Physics Degree in 1974 and graduated in Medicine from the University of Cologne in 1975. He obtained his MD in 1977 and trained in General Medicine and Endocrinology at the University Hospital Cologne. He received basic science training under the auspices of John Landon at Ba...

B Spiegelman, Dana-Farber Cancer Institute, Boston, United States. AbstractA professor of Cell Biology at Dana-Farber and Harvard Medical School, Spiegelman earned his undergraduate degree with highest honours from the College of William and Mary in Williamsburg, Va., and his PhD in biochemistry from Princeton University. He completed his postdoctoral work at the Massachusetts Institute of Technology.<p class="abst...

The hypothalamic-pituitary-gonadal (HPG) axis is a dynamic endocrine axis, with three main periods of activity - in foetal life, during mini-puberty, and then from puberty into adult reproductive life. Between these periods the axis is dormant and thus difficult to assess, especially in mid-childhood. Inhibin B and anti-Mullerian hormone (AMH) are both markers of gonadal function - of Sertoli cells of the testes and granulosa cells of the ovary - and are very useful investigat...